The claisen condensation is a carboncarbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the. In a mixed claisen condensation or crossed claisen condensation, an ester enolate or ketone enolate is condensed with an ester that cannot form an enolate. Claisen condensation an overview sciencedirect topics. Because of this most crossed claisen reactions are usually not performed unless one reactant has no alpha hydrogens. An aldol condensation is a condensation reaction in organic chemistry in which an enol or an quantitative yields in. The etherification of alcohols or phenols and their subsequent claisen rearrangement under thermal conditions. The claisen condensation of ethyl acetate yields ethyl acetoacetate.
The magnesium oxide crystal has been applied as catalyst. Claisen rearrangement of allyl vinyl ethers, part ii. The organic chemistry notebook series, a didactical approach, n 10. The r group of the ester starting material, the alkoxide base, and the alcohol solvent are chosen to be the same to not end up with a mixture of products.
The aromatic claisen rearrangement is accompanied by a rearomatization. We also acknowledge previous national science foundation support under grant numbers 1246120, 1525057, and 14739. Claisen condensations between different ester reactants are called crossed claisen reactions. An aldol condensation is a condensation reaction in organic chemistry in which an enol or an quantitative yields in claisen. The aliphatic claisen rearrangement is a 3,3sigmatropic rearrangement in which an allyl vinyl ether is converted thermally to an unsaturated carbonyl compound. March 14, 2020 admin leave a comment on condensacion aldolica cruzada pdf. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The claisen condensation is an organic reaction used to form a carboncarbon bond between two ester molecules using an alkoxide base in alcohol to make a. Mechanism, references and reaction samples of the claisen schmidt condensation. It has also been observed that the reactants with substituent groups in either of the two aromatic rings undergo the claisen schmidt condensation at a slower rate than the unsubstituted reactants.
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